Impact of sensorimotor rhythm neurofeedback on quality of life in patients with medically-refractory seizures

Lauren Frey

Abstract


Introduction: Published studies suggest that augmentation of the sensorimotor rhythm (SMR), a commonly used neurofeedback protocol for patients with epilepsy, changes thalamocortical regulatory systems and increases cortical excitation thresholds. Recent meta-analyses showed that at least 50% of patients with medically refractory epilepsy had a post-therapy reduction in seizure frequency after neurofeedback training. However, data on neurofeedback outcomes outside of seizure frequency are limited. Methods: The records for all consecutive patients trained using SMR neurofeedback in the University of Colorado Neurofeedback Clinic prior to March 2015 (n = 9) were retrospectively reviewed, abstracted, and analyzed. Patients completed the
Quality of Life in Epilepsy-31 (QOLIE-31) survey as a part of their clinic intake interview and at intervals throughout their training. Results: 214 total training sessions were reviewed. The average total QOLIE-31 baseline score in our patients was 49.3 ± 8.8. Seven patients completed follow-up QOLIE-31 surveys with an average score of 54.9 ± 6.5. Seventy-eight percent of the patients had improvement in their QOLIE-31 scores with training. The largest absolute improvements were in the seizure worry and cognitive subscores of the QOLIE-31. Conclusion: In this small case series, SMR neurofeedback training modestly improved short-term follow-up QOLIE-31 scores in patients with epilepsy.

Keywords


Seizure; epilepsy; sensorimotor rhythm; neurofeedback; quality of life

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References


Borghs, S., de la Loge, C., & Cramer, J. A. (2012). Defining minimally important change in QOLIE-31 scores: Estimates from three placebo-controlled lacosamide trials in patients

with partial-onset seizures. Epilepsy and Behavior, 23(3), 230–234. http://dx.doi.org/10.1016/j.yebeh.2011.12.023

Fisher, R. S., Acevedo, C., Arzimanoglou, A., Bogacz, A., Cross, J. H., Elger, C. E., ... Wiebe, S. (2014). ILAE Official Report: A practical clinical definition of epilepsy. Epilepsia, 55(4),

–482. http://dx.doi.org/10.1111/epi.12550

Hermann, B. P., Seidenberg, M., & Bell, B. (2000). Psychiatric Comorbidity in chronic epilepsy: Identification, consequences, and treatment of major depression. Epilepsia, 41(Suppl. s2),

S31–S41. http://dx.doi.org/10.1111/j.1528-1157.2000.tb01522.x

Kwan, P., Arzimanoglou, A., Berg, A. T., Brodie, M. J., Hauser, W. A., Mathern, G. W., ... French, J. (2010). Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task

Force of the ILAE Commission on Therapeutic Strategies. Epilepsia, 51(6), 1069–1077. http://dx.doi.org/10.1111/j.1528-1167.2009.02397.x

Loring, D. W., Meador, K. J., & Lee, G. P. (2004). Determinants of quality of life in epilepsy. Epilepsy and Behavior, 5(6), 976–980. http://dx.doi.org/10.1016/j.yebeh.2004.08.019

Soutar, R., & Longo, R. (2011). Doing Neurofeedback: An Introduction. San Rafael, CA: ISNR Research Foundation.

Sterman, M. B. (2000). Basic concepts and clinical findings in the treatment of seizure disorders with EEG operant conditioning. Clinical EEG and Neuroscience, 31(1), 45–55.

http://dx.doi.org /10.1177/155005940003100111

Sterman, M. B., & Egner, T. (2006). Foundation and practice of neurofeedback for the treatment of epilepsy. Applied Psychophysiology and Biofeedback, 31, 21–35.

http://dx.doi.org/10.1007/s10484-006-9002-x

Tan, G., Thornby, J., Hammond, D. C., Strehl, U., Canady, B., Arnemann, K., & Kaiser, D. A. (2009). Meta-analysis of EEG biofeedback in treating epilepsy. Clinical EEG and

Neuroscience, 40(3), 173–179. http://dx.doi.org/10.1177/155005940904000310

Wiebe, S., Matijevic, S., Eliasziw, M., & Derry, P. A. (2002). Clinically important change in quality of life in epilepsy. Journal of Neurology, Neurosurgery, and Psychiatry, 73, 116–

http://dx.doi.org /10.1136/jnnp.73.2.116




DOI: http://dx.doi.org/10.15540/nr.3.1.3

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