Infra-Low Frequency Neurofeedback in Depression: Three case studies

Vera A. Grin-Yatsenko, Siegfried Othmer, Valery A. Ponomarev, Sergey A. Evdokimov, Yuri Y. Konoplev, Juri D. Kropotov

Abstract


Electroencephalographic (EEG) findings on depressive patients indicate theta and alpha activity higher than in normal controls. Extensive literature reports on the effectiveness of neurofeedback techniques in the treatment of cognitive and behavioral disorders by training the patients to modulate their brain activities, as reflected in their electroencephalogram.  Three unmedicated depressed individuals participated in this study of Infra Low Frequency Neurofeedback (ILF NF) training. Along with the pre- and post-treatment Depression Rating Scales assessment, quantitative EEGs (qEEG) were recorded in Eyes open and Eyes closed resting states and during the visual cued GO/NOGO task before and after 20 sessions of training. Along with remission of the clinical symptoms of depression, significant decrease of theta power over frontal and central areas was observed in all three patients under all test conditions. These qEEG dynamics might be a correlate of ILF NF related recovery of the appropriate level of frontal cortical activation.


Keywords


Neurophysiology, Neurofeedback, Depression, qEEG

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References


Allen, J. J., Iacono, W. G., Depue, R. A., & Arbisi, P. (1993). Regional electroencephalographic asymmetries in bipolar seasonal affective disorder before and after exposure to bright light. Biological Psychiatry, 33(8), 642-646. http://dx.doi.org/10.1016/0006-3223(93)90104-L

Arns, M., Drinkenburg, W. H., Fitzgerald, P. B., & Kenemans, J. L. (2012). Neurophysiological predictors of non-response to rTMS in depression. Brain Stimulation, 5(4), 569-576. http://dx.doi.org/10.1016/j.brs.2011.12.003

Arns, M., Bruder, G., Hegerl, U., Spooner, C., Palmer, D. M., Etkin, A. et al. (2015). EEG alpha asymmetry as a gender-specific predictor of outcome to acute treatment with different antidepressant medications in the randomized iSPOT-D study. Clinical Neurophysiology. http://dx.doi.org/10.1016/j.clinph.2015.05.032

Austin, M. P., Mitchell, P., & Goodwin, G. M. (2001). Cognitive deficits in depression possible implications for functional neuropathology. The British Journal of Psychiatry, 178(3), 200-206. http://dx.doi.org/10.1192/bjp.178.3.200

Ayers, M.E. (1987). Electroencephalographic neurofeedback and closed head injury of 250 individuals. In: National Head Injury Syllabus (pp. 380-392). Washington, DC: Head Injury Foundation.

Baehr, E., & Baehr, R. (1997). The use of neurofeedback as adjunctive therapeutic treatment for depression: Three case studies. Biofeedback, 25, 10-11.

Baehr, E., Rosenfeld, J. P., & Baehr, R. (1998). The clinical use of an alpha asymmetry biofeedback protocol in treatment of depressive disorders: two case studies. Journal of Neurotherapy, 2, 12-27.

Baehr, E., Rosenfeld, J. P., Baehr, R., & Earnest, C. (1998). Comparison of two EEG asymmetry indices in depressed patients vs. normal controls. International Journal of Psychophysiology, 31(1), 89-92. http://dx.doi.org/10.1016/S0167-8760(98)00041-5

Baehr, E., Rosenfeld, P., Baehr, R., & Earnest, C. (1999). Clinical use of an alpha asymmetry protocol in the treatment of depressive disorders. (pp.181-188). In J. R. Evans & A. Abarbanel (Eds.) Introduction to quantitative EEG and neurofeedback (pp. pp.181-188), New York: Academic Press.

Baehr, E., Rosenfeld, J. P., & Baehr, R. (2001). Clinical use of an alpha asymmetry neurofeedback protocol in the treatment of mood disorders: Follow-up study one to five years post therapy. Journal of Neurotherapy, 4(4), 11-18. http://dx.doi.org/10.1016/B978-012243790-8/50009-2

Brenner, R. P., Ulrich, R. F., Spiker, D. G., Sclabassi, R. J., Reynolds, C. F., Marin, R. S., & Boller, F. (1986). Computerized EEG spectral analysis in elderly normal, demented and depressed subjects. Electroencephalography and Clinical Neurophysiology, 64(6), 483-492. http://dx.doi.org/10.1016/0013-4694(86)90184-7

Broyd, S. J., Demanuele, C., Debener, S., Helps, S. K., James, C. J., & Sonuga-Barke, E. J. (2009). Default-mode brain dysfunction in mental disorders: a systematic review. Neuroscience & Biobehavioral Reviews, 33(3), 279-296. http://dx.doi.org/10.1016/j.neubiorev.2008.09.002

Bruder, G. E., Fong, R., Tenke, C. E., Leite, P., Towey, J. P., Stewart, J. E., et al. (1997). Regional brain asymmetries in major depression with or without an anxiety disorder: a quantitative electroencephalographic study. Biological Psychiatry, 41(9), 939-948. http://dx.doi.org/10.1016/S0006-3223(96)00260-0

Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008). The brain's default network: anatomy, function, and relevance to disease. Annals of the New York Academy of Sciences, 1124(1), 1-38. http://dx.doi.org/10.1196/annals.1440.011

Choi, S. W., Chi, S. E., Chung, S. Y., Kim, J. W., Ahn, C. Y., & Kim, H. T. (2011). Is alpha wave neurofeedback effective with randomized clinical trials in depression? A pilot study. Neuropsychobiology, 63(1), 43-51. http://dx.doi.org/10.1159/000322290

Cook, I. A., O'Hara, R., Uijtdehaage, S. H., Mandelkern, M., & Leuchter, A. F. (1998). Assessing the accuracy of topographic EEG mapping for determining local brain function. Electroencephalography and Clinical Neurophysiology, 107(6), 408-414. http://dx.doi.org/10.1016/S0013-4694(98)00092-3

Davidson, R. J. (1995). Cerebral asymmetry, emotion and affective style. In Davidson R.J., Hughdah K.E., (Ed.), Brain Asymmetry (pp. 107–123). Cambridge: MIT Press.

Davidson, R. J., & Henriques, J. (2000). Regional brain function in sadness and depression. Borod, J. C., (Ed.), The neuropsychology of emotion. Series in affective science (pp. 269-297). New York, NY, US: Oxford University Press.

Davidson, R. J., Lewis, D. A., Alloy, L. B., Amaral, D. G., Bush, G., Cohen, J. D., et al. (2002). Neural and behavioral substrates of mood and mood regulation. Biological Psychiatry, 52(6), 478-502. http://dx.doi.org/10.1016/S0006-3223(02)01458-0

Dias, Á. M., & van Deusen, A. (2011). A new neurofeedback protocol for depression. The Spanish Journal of Psychology, 14(01), 374-384. http://dx.doi.org/10.5209/rev_SJOP.2011.v14.n1.34

Earnest, C. (1999). Single case study of EEG asymmetry biofeedback for depression: An independent replication in an adolescent. Journal of Neurotherapy, 3(2), 28-35. http://dx.doi.org/10.1300/J184v03n02_04

Fingelkurts, A.A., Fingelkurts, A.A., Rytsälä, H., Suominen, K., Isometsä, E., Kähkönen, S. (2006). Composition of brain oscillations in ongoing EEG during major depression disorder. Neuroscience Research, 56, 133–144. http://dx.doi.org/10.1016/j.neures.2006.06.006

Grin-Yatsenko, V. A., Baas, I., Ponomarev, V. A., & Kropotov, J. D. (2009). EEG power spectra at early stages of depressive disorders. Journal of Clinical Neurophysiology, 26(6), 401-406. http://dx.doi.org/10.1097/WNP.0b013e3181c298fe

Grin-Yatsenko, V. A., Baas, I., Ponomarev, V. A., & Kropotov, J. D. (2010). Independent component approach to the analysis of EEG recordings at early stages of depressive disorders. Clinical Neurophysiology, 121(3), 281-289. http://dx.doi.org/10.1016/j.clinph.2009.11.015

Hammond, D. C. (2000). Neurofeedback treatment of depression with the Roshi. Journal of Neurotherapy, 4(2), 45-56. http://dx.doi.org/10.1300/J184v04n02_06

Henriques, J. B., & Davidson, R. J. (1990). Regional brain electrical asymmetries discriminate between previously depressed and healthy control subjects. Journal of Abnormal Psychology, 99(1), 22-31. http://dx.doi.org/10.1037/0021-843X.99.1.22

Iosifescu, D. V., Greenwald, S., Devlin, P., Mischoulon, D., Denninger, J. W., Alpert, J. E., & Fava, M. (2009). Frontal EEG predictors of treatment outcome in major depressive disorder. European Neuropsychopharmacology, 19(11), 772-777. doi:10.1016/j.euroneuro.2009.06.001

Jaworska, N., Blier, P., Fusee, W., & Knott, V. (2012). Alpha power, alpha asymmetry and anterior cingulate cortex activity in depressed males and females. Journal of Psychiatric Research, 46(11), 1483-1491. http://dx.doi.org/10.1016/j.jpsychires.2012.08.003

Jensen, M. P., Grierson, C., Tracy-Smith, V., Bacigalupi, S. C., & Othmer, S. (2007). Neurofeedback treatment for pain associated with complex regional pain syndrome type I. Journal of Neurotherapy, 11(1), 45-53. http://dx.doi.org/10.1300/J184v11n01_04

John, E. R., Prichep, L. S., Fridman, J., & Easton, P. (1988). Neurometrics: computer-assisted differential diagnosis of brain dysfunctions. Science, 239(4836), 162-169. http://dx.doi.org/10.1126/science.3336779

Knott, V. J., Telner, J. I., Lapierre, Y. D., Browne, M., & Horn, E. R. (1996). Quantitative EEG in the prediction of antidepressant response to imipramine. Journal of Affective Disorders, 39(3), 175-184. http://dx.doi.org/10.1016/0165-0327(96)00003-1

Korb, A. S., Cook, I. A., Hunter, A. M., & Leuchter, A. F. (2008). Brain electrical source differences between depressed subjects and healthy controls. Brain Topography, 21(2), 138-146. http://dx.doi.org/10.1007/s10548-008-0070-5

Kropotov, J. (2009). Quantitative EEG, event-related potentials and neurotherapy. San Diego: Academic Press/Elsevier.

Kwon, J. S., Youn, T., & Jung, H. Y. (1996). Right hemisphere abnormalities in major depression: quantitative electroencephalographic findings before and after treatment. Journal of Affective Disorders, 40(3), 169-173. http://dx.doi.org/10.1016/0165-0327(96)00057-2

Legarda, S. B., McMahon, D., Othmer, S., & Othmer, S. (2011). Clinical neurofeedback: case studies, proposed mechanism, and implications for pediatric neurology practice. Journal of Child Neurology, 26(8), 1045-1051. http://dx.doi.org/10.1177/0883073811405052

Lieber, A. L., & Newbury, N. D. (1988). Diagnosis and subtyping of depressive disorders by quantitative electroencephalography: III. Discriminating unipolar from bipolar depression. Hillside Journal of Clinical Psychiatry, 10(2):165-172.

Lorincz, M. L., Geall, F., Bao, Y., Crunelli, V., & Hughes, S. W. (2009). ATP-dependent infra-slow (< 0.1 Hz) oscillations in thalamic networks. PLoS One, 4(2), e4447. http://dx.doi.org/ 10.1371/journal.pone.0004447

Menon, V. (2011). Large-scale brain networks and psychopathology: a unifying triple network model. Trends in Cognitive Sciences, 15(10), 483-506. http://dx.doi.org/10.1016/j.tics.2011.08.003

Olbrich, S., & Arns, M. (2013). EEG biomarkers in major depressive disorder: discriminative power and prediction of treatment response. International Review of Psychiatry, 25(5), 604-618. http://dx.doi.org/10.3109/09540261.2013.816269

Othmer, S. (1994). Depression. In Training Syllabus. Vol. 2. Encino, CA: EEG spectrum.

Othmer, S., Othmer, S. F., & Kaiser, D. A. (1999). EEG biofeedback: An emerging model for its global efficacy. In J. R. Evans & A. Abarbanel (Eds.) Introduction to quantitative EEG and neurofeedback (pp. 243-310), San Diego: Academic Press.

Othmer, S., & Othmer, S. F. (2009). Post traumatic stress disorder-The neurofeedback Remedy. Biofeedback, 37(1), 24-31. https://doi.org/10.5298/1081-5937-37.1.24

Othmer, S., Othmer, S., & Legarda, S. B. (2011). Clinical neurofeedback: training brain behavior. Treatment Strategies – Pediatric Neurology and Psychiatry, 2(1), 67-73.

Othmer, S., Othmer, S. F., Kaiser, D. A., & Putman, J. (2013). Endogenous neuromodulation at infralow frequencies. Seminars in Pediatric Neurology, 20(4), 246-257. http://dx.doi.org/10.1016/j.spen.2013.10.006

Othmer, S.F. (2015). The Protocol Guide for Neurofeedback Clinicians (5th Edition). EEG Info, Los Angeles, CA.

Pizzagalli, D. A., Oakes, T. R., & Davidson, R. J. (2003). Coupling of theta activity and glucose metabolism in the human rostral anterior cingulate cortex: an EEG/PET study of normal and depressed subjects. Psychophysiology, 40(6), 939-949. http://dx.doi.org/10.1111/1469-8986.00112

Pollock, V. E., & Schneider, L. S. (1990). Topographic quantitative EEG in elderly subjects with major depression. Psychophysiology, 27(4), 438-444. http://dx.doi.org/10.1111/j.1469-8986.1990.tb02340.x

Porter, R. J., Gallagher, P., Thompson, J. M., & Young, A. H. (2003). Neurocognitive impairment in drug-free patients with major depressive disorder. The British Journal of Psychiatry, 182(3), 214-220. http://dx.doi.org/10.1192/bjp.182.3.214

Raichle, M. E. (2011). The restless brain. Brain Connectivity, 1(1), 3-12. http://dx.doi.org/10.1089/brain.2011.0019

Roemer, R. A., Shagass, C., Dubin, W., Jaffe, R., & Siegal, L. (1992). Quantitative EEG in elderly depressives. Brain Topography, 4(4), 285-290. http://dx.doi.org/10.1007/BF01135566

Rosenfeld, J. P., Baehr, E., Baehr, R., Gotlib, I. H., & Ranganath, C. (1996). Preliminary evidence that daily changes in frontal alpha asymmetry correlate with changes in affect in therapy sessions. International Journal of Psychophysiology, 23(1), 137-141. http://dx.doi.org/10.1016/0167-8760(96)00037-2

Rosenfeld, J. P. (2000). An EEG biofeedback protocol for affective disorders. Clinical EEG and Neuroscience, 31(1), 7-12. http://dx.doi.org/10.1177/155005940003100106

Schacter, D. L. (1977). EEG theta waves and psychological phenomena: A review and analysis. Biological Psychology, 5(1), 47-82. http://dx.doi.org/10.1016/0301-0511(77)90028-X

Shankman, S. A., & Klein, D. N. (2003). The relation between depression and anxiety: an evaluation of the tripartite, approach-withdrawal and valence-arousal models. Clinical Psychology Review, 23(4), 605-637. http://dx.doi.org/10.1016/S0272-7358(03)00038-2

Sterman, M.B., Friar, L. (1972). Suppression of seizures in an epileptic following sensorimotor EEG feedback training. Electroencephalography and Clinical Neurophysiology, 33, 89-95. http://dx.doi.org/10.1016/0013-4694(72)90028-4

Strijkstra, A. M., Beersma, D. G., Drayer, B., Halbesma, N., & Daan, S. (2003). Subjective sleepiness correlates negatively with global alpha (8–12 Hz) and positively with central frontal theta (4–8 Hz) frequencies in the human resting awake electroencephalogram. Neuroscience Letters, 340(1), 17-20.

Suffin, S. C., & Emory, W. H. (1995). Neurometric subgroups in attentional and affective disorders and their association with pharmacotherapeutic outcome. Clinical EEG and Neuroscience, 26(2), 76-83. http://dx.doi.org/10.1177/155005949502600204

Tomarken, A.J., & Keener, A. D. (1998). Frontal brain asymmetry and depression: A self-regulatory perspective. Cognition & Emotion, 12(3), 387-420.

Vanhatalo, S., Palva, J. M., Holmes, M. D., Miller, J. W., Voipio, J., & Kaila, K. (2004). Infraslow oscillations modulate excitability and interictal epileptic activity in the human cortex during sleep. Proceedings of the National Academy of Sciences of the United States of America, 101(14), 5053-5057. http://dx.doi.org/10.1073/pnas.0305375101

Van Putten, M. J., Tjepkema-Cloostermans, M. C., & Hofmeijer, J. (2015). Infraslow EEG activity modulates cortical excitability in postanoxic encephalopathy. Journal of Neurophysiology, 113(9), 3256-3267. http://dx.doi.org/10.1152/jn.00714.2014

Volf, N. V., & Passynkova, N. R. (2002). EEG mapping in seasonal affective disorder. Journal of Affective Disorders, 72(1), 61-69. http://dx.doi.org/10.1016/S0165-0327(01)00425-6

Yamada, M., Kimura, M., Mori, T., & Endo, S. (1995). EEG power and coherence in presenile and senile depression. Characteristic findings related to differences between anxiety type and retardation type. Nihon Ika Daigaku Zasshi, 62(2), 176-185. http://dx.doi.org/10.1272/jnms1923.62.176




DOI: https://doi.org/10.15540/nr.5.1.30

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