Zebrafish: An In Vivo Model For The Study Of Therapeutic Targets Of Epilepsy

  • Brindha Durairaj Department of Biochemistry, PSG College of Arts & Science, Coimbatore, Tamil Nadu, India
  • Ravikumar Manish Department of Biochemistry, PSG College of Arts & Science, Coimbatore, Tamil Nadu, India
Keywords: epilepsy, Seizures, Neurotransmitters, Zebrafish, Therapeutic targets

Abstract

Epilepsy is a common neurological disorder due to excessive brain cell activity. It is characterized by unpredictable seizures resulting in cognition. The release of abnormal electric discharge in the regions of the brain causes epileptic seizures. Neurotransmitters play an important role in normal functioning of the brain and thus alteration of these neurotransmitters are associated with epilepsy. Zebrafish model have recently become a focus for various neurological disorders because of its high genetic similarity when compared with those of humans. Zebrafish can be grown in large numbers and their embryos are optically clear allowing examination of individual genes. This review will look at the utility of the zebrafish in the study of various therapeutic targets of epilepsy such as GABA, AMPA, NMDA, histamine H3, and phosphodiesters.

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Published
2019-12-11
Section
Review Articles