Hemodynamic and Pulmonary Safety Profile of the Accelerated Neuroregulation Procedure


  • Andre Waismann, MD
  • Albert Kabemba, MD
  • Olga Medowska ANR Clinic
  • Robert Salzman
  • Cathy Philpott
  • Milesh M. Patel




opioid use disorder (OUD), accelerated neuroregulation (ANR), opioid dependency, opioid dependency treatment, ; opioid dependency treatment safety, ANR safety, ANR physiological response


Background. Opioid use disorder (OUD) affects an estimated 26.8 million people globally (Strang et al., 2020). In 2020, opioid overdose visits in the United States increased by 28 percent (Harringa, 2021). Opioid-dependent individuals now comprise an internationally and nationally recognized vulnerable population (Harringa, 2021). Effective, proven, and safe treatments for OUD are needed to improve quality of life and life expectancy and to decrease international and national costs of care for this vulnerable population (Florence et al., 2016). Accelerated neuroregulation (ANR) is an internationally recognized protocol for treatment of OUD and has been utilized for over 20 years in hospitals in Israel, Switzerland, Brazil, Georgia, and other countries. Methods. This study is a retrospective review conducted by a team of healthcare providers based on the medical record documentation of patients who underwent the ANR procedure and subsequent follow-up care at the ANR clinic located in Florida. Following review of clinical case data, a comparative of patient hemodynamic and pulmonary stability was selected as the criteria to evaluate the procedure’s safety.  Results. The study assessed a sample group of patients treated with the ANR procedure. The sample group consisted of 50 individuals who underwent the ANR procedure between November 2020 and February 2021. All patients treated during this period were included in the sample size, no exclusions were applied. Conclusion. The study analysis demonstrates that ANR procedures are a safe and effective treatment for OUD based on the stability of hemodynamic and pulmonary physiological response data.


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